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Extrachromosomal circular DNA in cancer: history, current knowledge, and methods

8 Mar 2022

Abstract excerpt

Extrachromosomal circular DNA (eccDNA) is a closed-circle, nuclear, nonplasmid DNA molecule found in all tested eukaryotes. eccDNA plays important roles in cancer pathogenesis, evolution of tumor heterogeneity, and therapeutic resistance. It is known under many names, including very large cancer-specific circular extrachromosomal DNA (ecDNA), which carries oncogenes and is often amplified in cancer cells. Our...

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PMID: 35277298
DOI: 10.1016/j.tig.2022.02.007

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