Article

Extrachromosomal DNA driven oncogene spatial heterogeneity and evolution in glioblastoma

2024-10-25

Abstract excerpt

Oncogene amplification on extrachromosomal DNA (ecDNA) is strongly associated with treatment resistance and shorter survival for patients with cancer, including patients with glioblastoma. The non-chromosomal inheritance of ecDNA during cell division is a major contributor to intratumoral genetic heterogeneity. At present, the spatial dynamics of ecDNA, and the impact on tumor evolutionary trajectories, are not we...

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Literature Corpus work: a5fd2d57-ad11-5cb5-a7ce-ddc1076a5c1a
DOI: 10.1101/2024.10.22.619657

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