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Article

Extrachromosomal DNA: shaping the evolutionary dynamics of cancer.

Trends in cancer - 1 Sept 2025

Haughey Magnus, Noorani Imran, Swanton Charles, Mischel Paul S, Werner Benjamin

Abstract excerpt

Cancers are complex, diverse, and elusive, with extrachromosomal DNA (ecDNA) recently emerging as a crucial player in driving the evolution of about 20% of all tumors. In this review we discuss open questions concerning the evolutionary role of ecDNA in tumor development, including tumorigenesis and metastatic seeding, the mutational landscape on ecDNA, the dynamic ecDNA genotype-phenotype map, the structural...

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Identifiers

PMID: 40640072
DOI: 10.1016/j.trecan.2025.06.004
PMCID: PMC12313332

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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