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A recipe for chaos: Extrachromosomal DNA and the hallmarks of cancer.

Cell - 16 Apr 2026

Wong Ivy Tsz-Lo, Bailey Chris, Wu Sihan, Henssen Anton G, Cravatt Benjamin F, Chen Zhijian J, Bafna Vineet, Jamal-Hanjani Mariam, Swanton Charlie, Chang Howard Y, Mischel Paul S

Abstract excerpt

Some aggressive cancers exhibit a level of rapid genome change and therapy resistance that is difficult to explain. Research over the past decade has shown that extrachromosomal DNA (ecDNA) can be the cause. When oncogenic genetic elements untether from chromosomes and no longer follow Mendelian inheritance, genomic chaos and accelerated evolution ensue, generating unique ecDNA biology and non-traditional...

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DNA
Mutation
Neoplasms

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 41997126
DOI: 10.1016/j.cell.2026.03.011
PMCID: PMC13094713

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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