Article

CRISPR-Cas9 induced formation of Myc-containing ecDNA drives carcinogenesis in mouse liver and cancer phenotypes in human cell models

2026-03-31

Abstract excerpt

<title>Abstract</title> <p>Over 40% of human cancers harbor extrachromosomal DNA (ecDNA), which correlates with therapy resistance and poor prognosis. Yet research is limited by a lack of robust de novo ecDNA models. We present a CRISPR-Cas9 based approach for generation of ecDNA in cell lines and mouse liver. In HEK293 cells, CRISPR-induced MYC-bearing ecDNA ([MYCcircle]) promoted cancer hallmarks, including enh...

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Literature Corpus work: dac93d39-9805-57f1-82cf-c3b578af118d
DOI: 10.21203/rs.3.rs-9185034/v1

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CRISPR-Cas9 induced formation of Myc-containing ecDNA drives carcinogenesis in mouse liver and cancer phenotypes in human cell modelsDOI 10.21203/rs.3.rs-9185034/v1Read

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