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Extrachromosomal Circular DNA: A New Target in Cancer

14 Apr 2022

Abstract excerpt

Genomic instability and amplification are intrinsically important traits determining the development and heterogeneity of tumors. The role of extrachromosomal circular DNA (eccDNA) in tumors has recently been highlighted. EccDNAs are unique genetic materials located off the chromosomal DNA. They have been detected in a variety of tumors. This review analyzes the mechanisms involved in the formation of eccDNAs and...

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PMID: 35494014
DOI: 10.3389/fonc.2022.814504

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