Article

DNA-damaging combination treatments impose genotype-specific constraints on hypermutator evolvability

2026-02-20

Abstract excerpt

Bacterial hypermutator strains drive rapid evolution of antibiotic resistance in chronic infections. Inspired by cancer therapy approaches that exploit synthetic lethality by targeting DNA repair deficiencies in hypermutator tumours, we tested whether pairing a conventional antibiotic with a secondary DNA-damaging agent could constrain hypermutator evolution in bacteria. Using high-throughput experimental evolutio...

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Literature Corpus work: 1667a869-ecda-587e-b224-1c293b238038
DOI: 10.64898/2026.02.20.706947

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