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Article

Drugging evolution of antibiotic resistance at a regulatory network hub.

Science advances - 23 Jun 2023

Zhai Yin, Pribis John P, Dooling Sean W, Garcia-Villada Libertad, Minnick P J, Xia Jun, Liu Jingjing, Mei Qian, Fitzgerald Devon M, Herman Christophe, Hastings P J, Costa-Mattioli Mauro, Rosenberg Susan M

Abstract excerpt

Evolution of antibiotic resistance is a world health crisis, fueled by new mutations. Drugs to slow mutagenesis could, as cotherapies, prolong the shelf-life of antibiotics, yet evolution-slowing drugs and drug targets have been underexplored and ineffective. Here, we used a network-based strategy to identify drugs that block hubs of fluoroquinolone antibiotic-induced mutagenesis. We identify a U.S. Food and Drug...

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Identifiers

PMID: 37352342
DOI: 10.1126/sciadv.adg0188
PMCID: PMC10289659

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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