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Article

Evolutionary action of mutations reveals antimicrobial resistance genes in Escherichia coli.

Nature communications - 9 Jun 2022

Marciano David C, Wang Chen, Hsu Teng-Kuei, Bourquard Thomas, Atri Benu, Nehring Ralf B, Abel Nicholas S, Bowling Elizabeth A, Chen Taylor J, Lurie Pamela D, Katsonis Panagiotis, Rosenberg Susan M, Herman Christophe, Lichtarge Olivier

Abstract excerpt

Since antibiotic development lags, we search for potential drug targets through directed evolution experiments. A challenge is that many resistance genes hide in a noisy mutational background as mutator clones emerge in the adaptive population. Here, to overcome this noise, we quantify the impact of mutations through evolutionary action (EA). After sequencing ciprofloxacin or colistin resistance strains grown...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 35680894
DOI: 10.1038/s41467-022-30889-1
PMCID: PMC9184624

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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