Article

Two Classes of DNA Gyrase Inhibitors Elicit Distinct Evolutionary Trajectories Toward Resistance in Gram-Negative Pathogens

2023-06-27

Abstract excerpt

Comprehensive knowledge of mechanisms driving the acquisition of antimicrobial resistance is essential for the development of new drugs with minimized resistibility. To gain this knowledge, we combine experimental evolution in a continuous culturing device, the morbidostat, with whole genome sequencing of evolving cultures followed by characterization of drug-resistant isolates. Here, this approach was used to ass...

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Literature Corpus work: d27b5cb2-866f-5b1d-9bff-b5635b40d5a2
DOI: 10.1101/2023.06.26.546596

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Two Classes of DNA Gyrase Inhibitors Elicit Distinct Evolutionary Trajectories Toward Resistance in Gram-Negative PathogensDOI 10.1101/2023.06.26.546596Read

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