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Article

Bacterial hypermutation: clinical implications.

Journal of medical microbiology - 1 May 2011

Jolivet-Gougeon Anne, Kovacs Bela, Le Gall-David Sandrine, Le Bars Hervé, Bousarghin Latifa, Bonnaure-Mallet Martine, Lobel Bernard, Guillé François, Soussy Claude-James, Tenke Peter

Abstract excerpt

Heritable hypermutation in bacteria is mainly due to alterations in the methyl-directed mismatch repair (MMR) system. MMR-deficient strains have been described from several bacterial species, and all of the strains exhibit increased mutation frequency and recombination, which are important mechanisms for acquired drug resistance in bacteria. Antibiotics select for drug-resistant strains and refine resistance...

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Identifiers

PMID: 21349992
DOI: 10.1099/jmm.0.024083-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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