Article
Antibiotic treatment enhances the genome-wide mutation rate of target cells.
Proceedings of the National Academy of Sciences of the United States of America - 3 May 2016
Long Hongan, Miller Samuel F, Strauss Chloe, Zhao Chaoxian, Cheng Lei, Ye Zhiqiang, Griffin Katherine, Te Ronald, Lee Heewook, Chen Chi-Chun, Lynch Michael
Abstract excerpt
Although it is well known that microbial populations can respond adaptively to challenges from antibiotics, empirical difficulties in distinguishing the roles of de novo mutation and natural selection have left several issues unresolved. Here, we explore the mutational properties of Escherichia coli exposed to long-term sublethal levels of the antibiotic norfloxacin, using a mutation accumulation design combined...
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