Article
Mutators can drive the evolution of multi-resistance to antibiotics.
PLoS genetics - 1 Jun 2023
Gifford Danna R, Berríos-Caro Ernesto, Joerres Christine, Suñé Marc, Forsyth Jessica H, Bhattacharyya Anish, Galla Tobias, Knight Christopher G
Abstract excerpt
Antibiotic combination therapies are an approach used to counter the evolution of resistance; their purported benefit is they can stop the successive emergence of independent resistance mutations in the same genome. Here, we show that bacterial populations with 'mutators', organisms with defects in DNA repair, readily evolve resistance to combination antibiotic treatment when there is a delay in reaching...
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