Article

Mutation bias influences the emergence and effects of antibiotic resistance

2026-08-21

Abstract excerpt

Evolution of antibiotic resistance is a major global public health problem. Rapid emergence of antibiotic resistance is often linked to hypermutator bacteria with defective DNA repair, leading to high mutation rates that are broadly advantageous. However, depending on which DNA repair pathway is dysfunctional, mutators may sample only specific types of mutations at a higher rate. Thus, their mutation spectrum can...

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Literature Corpus work: c1fd0a41-c882-5190-837c-d3d3eae00fcb
DOI: 10.64898/2026.08.18.745421

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