Article

The essential role of hypermutation in rapid adaptation to antibiotic stress

2018-09-20

Abstract excerpt

A common outcome of antibiotic exposure in patients and in vitro is the evolution of a hypermutator phenotype that enables rapid adaptation by pathogens. While hypermutation is a robust mechanism for rapid adaptation, it requires trade-offs between the adaptive mutations and the more common “hitchhiker” mutations that accumulate from the increased mutation rate. Using quantitative experimental evolution, we exami...

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Literature Corpus work: a4620a96-2a57-51ab-bc25-4920b872b8d4
DOI: 10.1101/422642

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