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Article

Emergence of mutHV76G in carbapenem-resistant Klebsiella pneumoniae disrupts DNA mismatch repair and results in a hypermutator phenotype.

Antimicrobial agents and chemotherapy - 2 Sept 2026

Cheng Shaoji, Clancy Cornelius J, Fleres Giuseppe, Badrane Hassan, Culyba Matthew J, Newbrough Anthony, Chen Liang, Nguyen M Hong

Abstract excerpt

Hypermutation-driven evolution is a major contributor to antibiotic resistance in some bacterial pathogens, but its role in Klebsiella pneumoniae remains poorly defined. We analyzed 11 KPC-producing ST258 K. pneumoniae isolates collected serially over ~4 years from a host with persistent colonization and recurrent infections. After >3 years, isolates acquired ceftazidime-avibactam (CZA) resistance with restored...

Read the complete abstract on PubMed

Topics

Klebsiella pneumoniae
Anti-Bacterial Agents
Animals
Microbial Sensitivity Tests
Carbapenems

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mice

Ceftazidime

DNA Mismatch Repair

Drug Combinations

Mutation

Azabicyclo Compounds

Bacterial Proteins

Humans

beta-Lactamases

Klebsiella Infections

Third Generation Cephalosporins

Phenotype

Drug Resistance, Multiple, Bacterial

Source

Identifiers

PMID: 42554629
DOI: 10.1128/aac.00189-26

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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Emergence of mutHV76G in carbapenem-resistant Klebsiella pneumoniae disrupts DNA mismatch repair and results in a hypermutator phenotype.PMID 42554629Read ↗

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