Article

Large scale laboratory evolution uncovers clinically relevant collateral antibiotic sensitivity

2025-02-08

Abstract excerpt

The increasing prevalence of antibiotic resistance is a critical challenge, necessitating the development of strategies to mitigate the evolution of resistance. Collateral sensitivity (CS)-based sequential therapies have been proposed to mitigate resistance evolution. However, the evolutionary repeatability of CS across different experimental conditions and its clinical relevance remain underexplored, hindering it...

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Literature Corpus work: dea77df0-f8f9-535b-88c6-67a589ddc906
DOI: 10.1101/2025.02.07.637158

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