Article

GHT-SELEX demonstrates unexpectedly high intrinsic sequence specificity and complex DNA binding of many human transcription factors

2024-11-12

Abstract excerpt

<h4>SUMMARY</h4> Precise identification of transcription factor (TF) binding sites is a long standing challenge in human regulatory genomics: TF binding motifs are short and degenerate, while the genome is large. Motif scans, therefore, often produce excessive binding site predictions. By surveying 179 TFs across 25 families using >1,500 cyclic in vitro selection experiments with fragmented, naked, and unmodifie...

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Literature Corpus work: 993ad085-5141-5312-8740-fe799f51dcd3
DOI: 10.1101/2024.11.11.618478

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