Article

Codebook: sequence specificity and genomic binding of poorly-characterized human transcription factors

2024-11-12

Abstract excerpt

<h4>SUMMARY</h4> Gene expression is regulated by transcription factors (TFs), which recognize specific DNA sequence motifs. Several hundred putative human TFs, identified mainly by an apparent DNA-binding domain, lack known binding motifs 1 , and even for well-characterized TFs, it remains controversial to what degree motifs accurately reflect binding sites in living cells 2,3 . Here, we describe a systematic e...

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Literature Corpus work: dc570702-c545-5e7a-9a94-6a5aaa4364f9
DOI: 10.1101/2024.11.11.622097

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