Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Compendium of human transcription factor effector domains.

Molecular cell - 3 Feb 2022

Soto Luis F, Li Zhaorong, Santoso Clarissa S, Berenson Anna, Ho Isabella, Shen Vivian X, Yuan Samson, Fuxman Bass Juan I

Abstract excerpt

Transcription factors (TFs) regulate gene expression by binding to DNA sequences and modulating transcriptional activity through their effector domains. Despite the central role of effector domains in TF function, there is a current lack of a comprehensive resource and characterization of effector domains. Here, we provide a catalog of 924 effector domains across 594 human TFs. Using this catalog, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to DNA
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Protein Binding

Share to Protein Domains

Share to Transcription Factors

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 34863368
DOI: 10.1016/j.molcel.2021.11.007
PMCID: PMC8818021

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Compendium of human transcription factor effector domains.PMID 34863368Read ↗

Large-scale mapping and systematic mutagenesis of human transcriptional effector domainsSemantic proximity Read ↗

Codebook: sequence specificity and genomic binding of poorly-characterized human transcription factorsSemantic proximity Read ↗

Systematic target function annotation of human transcription factors.Semantic proximity Read ↗

HEDD: Human Enhancer Disease Database.Semantic proximity Read ↗

Past, present, and future perspectives of transcription factor EB (TFEB): mechanisms of regulation and association with diseaseSemantic proximity Read ↗

A GO catalogue of human DNA-binding transcription factorsSemantic proximity Read ↗

A Comprehensive Annotation of Conserved Protein Domains in Human Endogenous RetrovirusesSemantic proximity Read ↗

Classification of Human Transcription Factors Based on Their Effector Domains via Unsupervised LearningSemantic proximity Read ↗

Disordered but Different: Functional and Evolutionary Divergence of Transcription Factor Intrinsically Disordered RegionsSemantic proximity Read ↗

Comprehensive Analysis of the Human SH3 Domain Family Reveals a Wide Variety of Non-canonical SpecificitiesSemantic proximity Read ↗

A comprehensive manually-curated Compendium of Bovine Transcription FactorsSemantic proximity Read ↗

Identification and catalogue of viral transcriptional regulators in human diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.