Article

Dot1L licenses DNA demethylation to establish regulatory T cell identity

2025-12-07

Abstract excerpt

Foxp3 + regulatory T (T reg ) cells rely on DNA demethylation to establish and maintain the gene expression program that defines their identity and suppressive function. Although sustained transcription of Treg-specific genes is known to drive this demethylation, the precise mechanism has remained unclear. Here, we show that Dot1L-catalyzed methylation of histone H3 at lysine 79 (H3K79me) is essential for Treg-s...

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Literature Corpus work: 148342cb-c507-5719-91e1-54f9be545761
DOI: 10.64898/2025.12.03.692152

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