Article

Loss of TET proteins in regulatory T cells unleashes effector function

2019-02-15

Abstract excerpt

TET enzymes oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and other oxidized methylcytosines, mediating DNA demethylation and serving as new epigenetic marks. Here we examine the role of TET proteins in Foxp3 + regulatory T (Treg) cells, a distinct lineage of CD4 + T cells that prevent autoimmunity and maintain immune homeostasis. We report that Tet2/3 fl/fl Foxp3 Cre mice that lack Tet2 and...

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Identifiers and source

Literature Corpus work: 17e64a19-1d16-5ea9-8d2b-58d0209e93db
DOI: 10.1101/551093

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