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Epigenetic priming by Dot1l in lymphatic endothelial progenitors ensures normal lymphatic development and function

6 Jan 2020

Abstract excerpt

Proper functioning of the lymphatic system is required for normal immune responses, fluid balance, and lipid reabsorption. Multiple regulatory mechanisms are employed to ensure the correct formation and function of lymphatic vessels; however, the epigenetic modulators and mechanisms involved in this process are poorly understood. Here, we assess the regulatory role of mouse Dot1l, a histone H3 lysine (K) 79...

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PMID: 31908356
DOI: 10.1038/s41419-019-2201-1

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