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Article

FoxP3 and Ezh2 regulate Tfr cell suppressive function and transcriptional program

31 Jan 2019

Abstract excerpt

Follicular regulatory T (Tfr) cells are a regulatory T cell subset that controls antibody production by inhibiting T follicular helper (Tfh)-mediated help to B cells. Tfh and Tfr cells possess opposing functions suggesting unique programming. Here we elucidated the transcriptional program controlling Tfr suppressive function. We found that Tfr cells have a program for suppressive function fine-tuned by tissue...

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Identifiers

PMID: 30705058
DOI: 10.1084/jem.20181134

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