Article

Comprehensively characterizing evolutionarily conserved differential dosage compensations of the X chromosome during development and in diseases

2022-07-25

Abstract excerpt

The active X chromosome in mammals is upregulated to balance its dosage to autosomes during evolution. However, it is elusive why the currently known dosage compensation machinery showed uneven and small influence on X genes, necessitating systemic investigation of X dosage in different angles and identification of new dosage regulators. Here, based on >20,000 transcriptomes, we identified two X gene groups (genom...

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Literature Corpus work: a5e09a0b-653c-5ef7-86e1-bd0fc31a89eb
DOI: 10.1101/2022.07.25.501478

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