Article

Dosage sensitivity of X-linked genes in human embryonic single cells

2018-03-29

Abstract excerpt

<h4>ABSTRACT</h4> Fifty years ago, Susumu Ohno proposed that the expression levels of X-linked genes have doubled as dosage compensation for autosomal genes due to degeneration of Y-linked homologs during evolution of mammalian sex chromosomes. Recent studies have nevertheless shown that the X to autosome expression ratio equals ~1 in haploid human parthenogenetic embryonic stem (pES) cells and ~0.5 in diploid pE...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a81fd3c5-d8f9-5edf-89ef-08b83e976e95
DOI: 10.1101/291724

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dosage sensitivity of X-linked genes in human embryonic single cellsDOI 10.1101/291724Read

Early X chromosome inactivation during human preimplantation development revealed by single-cell RNA-sequencing.Semantic proximity Read

X-chromosome dosage compensation dynamics in human early embryosSemantic proximity Read

Expression reduction of biallelically transcribed X-linked genes during the human female preimplantation developmentSemantic proximity Read

Dynamic Spatial-Temporal Expression Ratio of X Chromosome to Autosomes but Stable Dosage Compensation in MammalsSemantic proximity Read

Single-cell RNA-seq reveals distinct dynamic behavior of sex chromosomes during early human embryogenesisSemantic proximity Read

Transcriptional kinetics of X-chromosome upregulationSemantic proximity Read

Elastic dosage compensation by X-chromosome upregulation.Semantic proximity Read

Stable and robust Xi and Y transcriptomes drive cell-type-specific autosomal and Xa responses <i>in vivo</i> and <i>in vitro</i> in four human cell typesSemantic proximity Read

X-factors in human disease: impact of gene content and dosage regulation.Semantic proximity Read

The human Y and inactive X chromosomes similarly modulate autosomal gene expressionSemantic proximity Read

Mechanistic diversification of <i>XIST</i> regulatory network in mammalsSemantic proximity Read

Evolutionary origins and chromatin state shape X-chromosome upregulation pattern during eutherian and metatherian embryogenesisSemantic proximity Read