Article

Sex Chromosome Dosage Effects On Gene Expression In Humans

2017-05-14

Abstract excerpt

<h4>ABSTRACT</h4> A fundamental question in the biology of sex-differences has eluded direct study in humans: how does sex chromosome dosage (SCD) shape genome function? To address this, we developed a systematic map of SCD effects on gene function by analyzing genome-wide expression data in humans with diverse sex chromosome aneuploidies (XO, XXX, XXY, XYY, XXYY). For sex chromosomes, we demonstrate a pattern of...

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Literature Corpus work: 0eb6dfd8-bbb8-5e35-a83e-5a3ec5a91bba
DOI: 10.1101/137752

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