Article

Lineage specific core-regulatory circuits determine gene essentiality in cancer cells

2019-04-16

Abstract excerpt

<h4>ABSTRACT</h4> Cancer cells rely on dysregulated gene expression programs to maintain their malignant phenotype. A cell’s transcriptional state is controlled by a small set of interconnected transcription factors that form its core-regulatory circuit (CRC). Previous work in pediatric cancers has shown, that disruption of the CRC by genetic alterations causes tumor cells to become highly dependent on its compon...

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Literature Corpus work: 0fbf063a-80e1-56ca-bc45-0b98c7517a75
DOI: 10.1101/609552

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