Article

Genetic mechanisms for tissue-specific essential genes

2021-04-09

Abstract excerpt

Genetic diseases often manifest in specific tissues despite having the genetic risk variants in all cells. The most commonly assumed mechanism is selective expression of the causal gene in the pathogenic tissues, but other mechanisms are less explored. Using CRISPR screens from 789 cell lines and 27 lineages, we identified 1274 lineage-specific essential genes (LSEGs). We show that only a minority of LSEGs are exp...

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Literature Corpus work: 84864f34-78ba-5873-a309-00d31f212064
DOI: 10.1101/2021.04.09.438977

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