Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer.

doi:10.1073/pnas.1109363108

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer.

Proceedings of the National Academy of Sciences of the United States of America - 26 Jul 2011

Cheung Hiu Wing, Cowley Glenn S, Weir Barbara A, Boehm Jesse S, Rusin Scott, Scott Justine A, East Alexandra, Ali Levi D, Lizotte Patrick H, Wong Terence C, Jiang Guozhi, Hsiao Jessica, Mermel Craig H, Getz Gad, Barretina Jordi, Gopal Shuba, Tamayo Pablo, Gould Joshua, Tsherniak Aviad, Stransky Nicolas, Luo Biao, Ren Yin, Drapkin Ronny, Bhatia Sangeeta N, Mesirov Jill P, Garraway Levi A, Meyerson Matthew, Lander Eric S, Root David E, Hahn William C

Abstract excerpt

A comprehensive understanding of the molecular vulnerabilities of every type of cancer will provide a powerful roadmap to guide therapeutic approaches. Efforts such as The Cancer Genome Atlas Project will identify genes with aberrant copy number, sequence, or expression in various cancer types, p...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Oxidoreductases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Survival

Share to Oncogenes

Share to Ovarian Neoplasms

Share to Paired Box Transcription Factors

Share to PAX8 Transcription Factor

Share to RNA, Neoplasm

Share to RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 21746896
DOI: 10.1073/pnas.1109363108
PMCID: PMC3145679

Genes

PAX8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21746896-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer.PMID 21746896Read ↗

Non-coding somatic mutations converge on the PAX8 pathway in ovarian cancer.Semantic proximity Read ↗

Uncoupling of gene expression from copy number presents therapeutic opportunities in aneuploid cancersSemantic proximity Read ↗

Lineage specific core-regulatory circuits determine gene essentiality in cancer cellsSemantic proximity Read ↗

Integrated Genomic, Epigenomic, and Expression Analyses of Ovarian Cancer Cell LinesSemantic proximity Read ↗

Reproducible autosomal gene expression changes with loss of typical X and Y complement across tumor typesSemantic proximity Read ↗

Interpreting pathways to discover cancer driver genes with Moonlight.Semantic proximity Read ↗

Functional Genomic Analysis of CDK4 and CDK6 Gene Dependency across Human Cancer Cell LinesSemantic proximity Read ↗

Highly parallel identification of essential genes in cancer cellsSemantic proximity Read ↗

Coessentiality and cofunctionality: a network approach to learning genetic vulnerabilities from cancer cell line fitness screensSemantic proximity Read ↗

Paired-Box genes are frequently expressed in cancer and often required for cancer cell survival.Semantic proximity Read ↗

Functional genomics identifies five distinct molecular subtypes with clinical relevance and pathways for growth control in epithelial ovarian cancerSemantic proximity Read ↗

Systematic lncRNA mapping to genome-wide co-essential pathways uncovers cancer dependency on uncharacterized lncRNAsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.