Article

Predicting master transcription factors from pan-cancer expression data

2019-11-12

Abstract excerpt

The function of critical developmental regulators can be subverted by cancer cells to control expression of oncogenic transcriptional programs. These "master transcription factors" (MTFs) are often essential for cancer cell survival and represent vulnerabilities that can be exploited therapeutically. The current approaches to identify candidate MTFs examine super-enhancer associated transcription factor-encoding g...

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Literature Corpus work: 0f2399c9-5ca7-559c-a638-be0e2a214512
DOI: 10.1101/839142

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