Article

Deciphering Precursor Cell Dynamics in Esophageal Preneoplasia via Genetic Barcoding and Single-Cell Transcriptomics

2025-02-26

Abstract excerpt

Although histologically normal, esophageal preneoplastic cells harbor early genetic alterations and likely exhibit lineage plasticity. However, their origins and trajectories remain unclear. To address this, we combined genetic barcoding with single-cell RNA sequencing to trace the lineage of esophageal preneoplastic cells. We identified a distinct progenitor-like cell population with high plasticity. Through a ne...

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Literature Corpus work: 6271c4ab-6388-5461-b6e0-cf2a745e76f5
DOI: 10.1101/2025.02.26.637920

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