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Article

Lineage-Selective Dependencies in Pediatric Cancers.

Cold Spring Harbor perspectives in medicine - 1 Apr 2025

Ritter K Elaine, Durbin Adam D

Abstract excerpt

The quest for effective cancer therapeutics has traditionally centered on targeting mutated or overexpressed oncogenic proteins. However, challenges arise in cancers with low mutational burden or when the mutated oncogene is not conventionally targetable, which are common situations in childhood cancers. This obstacle has sparked large-scale unbiased screens to identify collateral genetic dependencies crucial for...

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Identifiers

PMID: 38806246
DOI: 10.1101/cshperspect.a041573
PMCID: PMC11882016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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