Article

Lineage transcription factors co-regulate subtype-specific genes providing a roadmap for systematic identification of small cell lung cancer vulnerabilities

2020-08-14

Abstract excerpt

<h4>ABSTRACT</h4> Lineage-defining transcription factors (LTFs) play key roles in tumor cell growth, making them highly attractive, but currently “undruggable”, small cell lung cancer (SCLC) vulnerabilities. Delineating LTF genomic binding sites and associated chromatin features would provide important insights into SCLC dependencies. Here we map super-enhancers (SEs) across multiple patient-derived SCLC preclini...

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Literature Corpus work: 45fd7024-cf10-5f41-95ed-12d0f6498796
DOI: 10.1101/2020.08.13.249029

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