Article

Pan-cancer Analysis Identified Ectopic RUNX1T1 Associated with Lineage Plasticity

2025-04-23

Abstract excerpt

Cancer remains a leading cause of death worldwide, with lineage plasticity emerging as a hallmark that drives therapy resistance and tumor progression, allowing cancer cells to rapidly alter their identity and evade targeted therapies. Although various genomic and transcriptomic aberrations correlate with lineage plasticity, the lack of pan-cancer gene markers quantifying lineage plasticity has limited its utility...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d4ed1201-3cb4-5be2-b254-a253f9e0291a
DOI: 10.1101/2025.04.18.649575

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pan-cancer Analysis Identified Ectopic RUNX1T1 Associated with Lineage PlasticityDOI 10.1101/2025.04.18.649575Read

RUNX1T1-HDAC Reprogramming of the HOX Code Signaling Drives a Targetable Pan-Cancer Lineage PlasticitySemantic proximity Read

The Transcriptional and Epigenetic Landscape of Cancer Cell Lineage PlasticitySemantic proximity Read

A single cell framework for multi-omic analysis of disease identifies malignant regulatory signatures in mixed phenotype acute leukemiaSemantic proximity Read

Integrated single-cell transcriptomic analyses identify a novel lineage plasticity-related cancer cell type involved in prostate cancer progressionSemantic proximity Read

Single-cell Transcriptional Atlas of Human Hematopoiesis Reveals Genetic and Hierarchy-Based Determinants of Aberrant AML DifferentiationSemantic proximity Read

Data-driven Understanding On Cancer Lineage Plasticity: Examples and ChancesSemantic proximity Read

Genetic barcoding of individual cells links cancer evolutionary trajectories and prognostic outcomesSemantic proximity Read

Lineage Plasticity and Stemness Phenotypes in Prostate Cancer: Harnessing the Power of Integrated “Omics” Approaches to Explore Measurable MetricsSemantic proximity Read

Lineage Plasticity in Cancer: The Tale of a Skin-WalkerSemantic proximity Read

Multi-omic lineage tracing predicts the transcriptional, epigenetic and genetic determinants of cancer evolutionSemantic proximity Read

Multi-omic lineage tracing predicts the transcriptional, epigenetic and genetic determinants of cancer evolution.Semantic proximity Read

PROX1 is an early driver of lineage plasticity in prostate cancerSemantic proximity Read