Article

Rewiring of chromatin loops in adipogenesis reveals targets for obesity and diabetes intervention

2023-06-30

Abstract excerpt

Adipogenesis is a multi-stage process essential for healthy fat storage and metabolic regulation. While early regulatory mechanisms are well characterized, the control of late-stage adipocyte differentiation remains poorly understood. Integrating CAGE-seq, promoter capture Hi-C, and a high-throughput siRNA screen of druggable genes, we report here that chromatin architecture rewiring promotes gene regulation chang...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0ddba06d-025e-5cf6-b0a0-b46907da3fca
DOI: 10.1101/2023.06.27.546683

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rewiring of chromatin loops in adipogenesis reveals targets for obesity and diabetes interventionDOI 10.1101/2023.06.27.546683Read

Energy Conservation Drives Adaptive Specialization Through Fine-tuned OrganizationsSemantic proximity Read

Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetesSemantic proximity Read

A functional genomics pipeline identifies pleiotropy and cross-tissue effects within obesity-associated GWAS loci.Semantic proximity Read

Detecting epistasis within chromatin regulatory circuitry reveals CAND2 as a novel susceptibility gene for obesity.Semantic proximity Read

Context Dependent Perturbation of Allelic Expression Imbalance Reveals Novel Candidate Therapeutic Targets for Metabolic diseasesSemantic proximity Read

Epigenome Alterations and 3D Chromatin Architecture Remodeling in Inflammatory Macrophage Activation under Diabetic ConditionsSemantic proximity Read

Adipose single cell epigenome and transcriptome localize genetic risk for cardiometabolic disease and accelerated aging.Semantic proximity Read

Epigenomic and Transcriptomic Prioritization of Candidate Obesity-Risk Regulatory GWAS SNPs.Semantic proximity Read

3D chromatin organization changes modulate adipogenesis and osteogenesisSemantic proximity Read

Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS.Semantic proximity Read

Systematic functional characterization of non-coding regulatory SNPs associated with central obesity.Semantic proximity Read

3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity.Semantic proximity Read