Article
3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity.
eLife - 15 Jan 2025
Trang Khanh B, Pahl Matthew C, Pippin James A, Su Chun, Littleton Sheridan H, Sharma Prabhat, Kulkarni Nikhil N, Ghanem Louis R, Terry Natalie A, O'Brien Joan M, Wagley Yadav, Hankenson Kurt D, Jermusyk Ashley, Hoskins Jason, Amundadottir Laufey T, Xu Mai, Brown Kevin, Anderson Stewart, Yang Wenli, Titchenell Paul, Seale Patrick, Kaestner Klaus H, Cook Laura, Levings Megan, Zemel Babette S, Chesi Alessandra, Wells Andrew D, Grant Struan F A
Abstract excerpt
The prevalence of childhood obesity is increasing worldwide, along with the associated common comorbidities of type 2 diabetes and cardiovascular disease in later life. Motivated by evidence for a strong genetic component, our prior genome-wide association study (GWAS) efforts for childhood obesity revealed 19 independent signals for the trait; however, the mechanism of action of these loci remains to be...
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