Article

Epigenome Alterations and 3D Chromatin Architecture Remodeling in Inflammatory Macrophage Activation under Diabetic Conditions

2026-05-31

Abstract excerpt

Aberrant monocyte/macrophage activation in diabetes drives chronic inflammation and complications. While epigenetic mechanisms are implicated, the role of 3D-chromatin reorganization remains unclear. Using integrated multi-Omics, we profiled gene expression and 3D-chromatin architecture in human CD14 + monocyte-differentiated macrophages treated with high glucose + TNF-α (HT) mimicking the diabetic milieu. HT ind...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 49606b89-43fe-5f9c-bcf0-09760c8e892e
DOI: 10.64898/2026.05.27.727961

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Epigenome Alterations and 3D Chromatin Architecture Remodeling in Inflammatory Macrophage Activation under Diabetic ConditionsDOI 10.64898/2026.05.27.727961Read

Rewiring of chromatin loops in adipogenesis reveals targets for obesity and diabetes interventionSemantic proximity Read

Static and dynamic DNA loops form AP-1 bound activation hubs during macrophage developmentSemantic proximity Read

Static and Dynamic DNA Loops form AP-1-Bound Activation Hubs during Macrophage Development.Semantic proximity Read

Rewiring of 3D Enhancer-Promoter Interactome Underlies Diabetic Endothelial DysfunctionSemantic proximity Read

An enhancer-centric approach applied to human immune system epigenomes revealed the association of macrophage enhancers with cardiovascular diseaseSemantic proximity Read

Regulation of inflammation in diabetes: From genetics to epigenomics evidence.Semantic proximity Read

Two distinct chromatin modules regulate proinflammatory gene expressionSemantic proximity Read

Scalable ultra-high-throughput single-cell chromatin and RNA sequencing reveals gene regulatory dynamics linking macrophage polarization to autoimmune diseaseSemantic proximity Read

Human pancreatic islet 3D chromatin architecture provides insights into the genetics of type 2 diabetesSemantic proximity Read

scMEGA: single-cell multi-omic enhancer-based gene regulatory network inferenceSemantic proximity Read

The three-dimensional chromatin structure of the major human pancreatic cell types reveals lineage-specific regulatory architecture of T2D riskSemantic proximity Read

Chromatin conformation dynamics during CD4+ T cell activation implicates autoimmune disease-associated genes and regulatory elementsSemantic proximity Read