Article

3D chromatin organization changes modulate adipogenesis and osteogenesis

2020-05-27

Abstract excerpt

Human mesenchymal stem cells (hMSCs) can be differentiated into adipocytes and osteoblasts. While the transcriptomic and epigenomic changes during adipogenesis and osteogenesis have been characterized, what happens to the chromatin loops is hardly known. Here we induced hMSCs to adipogenic and osteogenic differentiation, and performed 2 kb resolution Hi-C experiments for loop detection and generated RNA-seq, histo...

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Literature Corpus work: ae60f267-bdbd-5fbb-b83e-c229e619d484
DOI: 10.1101/2020.05.25.114272

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