Article

Genetic identification of the RAS proteostatic machinery and its failure to regulate oncogenic variants

2025-12-11

Abstract excerpt

The regulation of cellular homeostasis, differentiation, and proliferation is safeguarded by proteostatic mechanisms, which are crucial for maintaining cellular function. We used endogenously affinity-tagged KRAS cells in a fluorescence-activated cell sorting (FACS)-based CRISPR knockout screen to map genome-wide genetic requirements for proteostatic KRAS regulation. Three regulatory modules emerged, specifically...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0c3176b6-6365-567a-a1b2-cf1264c76e9e
DOI: 10.64898/2025.12.10.693430

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic identification of the RAS proteostatic machinery and its failure to regulate oncogenic variantsDOI 10.64898/2025.12.10.693430Read

Oncogenic mutations of KRAS modulate its turnover by the CUL3/LZTR1 E3 ligase complex.Semantic proximity Read

A Comparative Analysis of Individual RAS Mutations in Cancer BiologySemantic proximity Read

Interplay Between KRAS and LZTR1 Protein Turnover, Controlled by CUL3/LZTR1 E3 Ubiquitin Ligase, is Disrupted by KRAS MutationsSemantic proximity Read

Targeting oncogenic Ras signaling in hematologic malignancies.Semantic proximity Read

The Ins and Outs of RAS Effector Complexes.Semantic proximity Read

Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activitySemantic proximity Read

The Abundance of KRAS and RAS Gene Mutations in Cancer.Semantic proximity Read

KRAS insertion mutations are oncogenic and exhibit distinct functional properties.Semantic proximity Read

Multiplexed identification of RAS paralog imbalance as a driver of lung cancer growthSemantic proximity Read

A Proteomic Approach Identifies Isoform-Specific and Nucleotide-Dependent RAS Interactions.Semantic proximity Read

Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers.Semantic proximity Read

A novel protein RASON encoded by a lncRNA controls oncogenic RAS signaling in KRAS mutant cancers.Semantic proximity Read