Article

Multiplexed identification of RAS paralog imbalance as a driver of lung cancer growth

2021-07-09

Abstract excerpt

<h4>ABSTRACT</h4> Oncogenic KRAS mutations occur in approximately 30% of lung adenocarcinoma. Despite several decades of effort, oncogenic KRAS-driven lung cancer remains difficult to treat, and our understanding of the positive and negative regulators of RAS signaling is incomplete. To uncover the functional impact of diverse KRAS-interacting proteins on lung cancer growth in vivo , we used multiplexed somatic...

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Literature Corpus work: 2a519a47-ad8e-5fce-aa78-8a4caf397e47
DOI: 10.1101/2021.07.08.451571

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