Article
Oncogenic mutations of KRAS modulate its turnover by the CUL3/LZTR1 E3 ligase complex.
Life science alliance - 1 May 2024
Damianou Andreas, Liang Zhu, Lassen Frederik, Vendrell Iolanda, Vere George, Hester Svenja, Charles Philip D, Pinto-Fernandez Adan, Santos Alberto, Fischer Roman, Kessler Benedikt M
Abstract excerpt
KRAS is a proto-oncogene encoding a small GTPase. Mutations contribute to ∼30% of human solid tumours, including lung adenocarcinoma, pancreatic, and colorectal carcinomas. Most KRAS activating mutations interfere with GTP hydrolysis, essential for its role as a molecular switch, leading to alterations in their molecular environment and oncogenic signalling. However, the precise signalling cascades these...
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