Article

Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity

2024-10-25

Abstract excerpt

To dissect variant-function relationships in the KRAS oncoprotein, we performed deep mutational scanning (DMS) screens for both wild-type and KRAS G12D mutant alleles. We defined the spectrum of oncogenic potential for nearly all possible KRAS variants, identifying several novel transforming alleles and elucidating a model to describe the frequency of KRAS mutations in human cancer as a function of transforming...

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Identifiers and source

Literature Corpus work: eaf94bdc-9d9c-5bce-9460-6666525df594
DOI: 10.1101/2024.10.22.618529

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