Article
Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers.
Cancer research - 2 Nov 2022
Scharpf Robert B, Balan Archana, Ricciuti Biagio, Fiksel Jacob, Cherry Christopher, Wang Chenguang, Lenoue-Newton Michele L, Rizvi Hira A, White James R, Baras Alexander S, Anaya Jordan, Landon Blair V, Majcherska-Agrawal Marta, Ghanem Paola, Lee Jocelyn, Raskin Leon, Park Andrew S, Tu Huakang, Hsu Hil, Arbour Kathryn C, Awad Mark M, Riely Gregory J, Lovly Christine M, Anagnostou Valsamo
Abstract excerpt
The RAS family of small GTPases represents the most commonly activated oncogenes in human cancers. To better understand the prevalence of somatic RAS mutations and the compendium of genes that are coaltered in RAS-mutant tumors, we analyzed targeted next-generation sequencing data of 607,863 mutations from 66,372 tumors in 51 cancer types in the AACR Project GENIE Registry. Bayesian hierarchical models were...
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