Article

Interplay Between KRAS and LZTR1 Protein Turnover, Controlled by CUL3/LZTR1 E3 Ubiquitin Ligase, is Disrupted by KRAS Mutations

2021-11-23

Abstract excerpt

<h4>ABSTRACT</h4> KRAS is a proto-oncogene encoding a small GTPase. Mutations contribute up to 30% of human solid tumours including lung adenocarcinoma, pancreatic and colorectal carcinomas. Most KRAS activating mutations interfere with GTP hydrolysis, essential for its role as a molecular switch, leading to alterations in their molecular environment and oncogenic signalling. Here, APEX-2 proximity labelling was...

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Literature Corpus work: b269e7b5-4e3b-561e-b7de-ddc4029b4daa
DOI: 10.1101/2021.11.23.469679

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