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Article

Targeting oncogenic Ras signaling in hematologic malignancies.

Blood - 25 Oct 2012

Ward Ashley F, Braun Benjamin S, Shannon Kevin M

Abstract excerpt

Ras proteins are critical nodes in cellular signaling that integrate inputs from activated cell surface receptors and other stimuli to modulate cell fate through a complex network of effector pathways. Oncogenic RAS mutations are found in ∼25% of human cancers and are highly prevalent in hematopoietic malignancies. Because of their structural and biochemical properties, oncogenic Ras proteins are exceedingly...

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Source

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Identifiers

PMID: 22898602
DOI: 10.1182/blood-2012-05-378596
PMCID: PMC3482854

Genes

KRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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