Article
A Proteomic Approach Identifies Isoform-Specific and Nucleotide-Dependent RAS Interactions.
Molecular & cellular proteomics : MCP - 1 Aug 2022
Miller Seth P, Maio George, Zhang Xiaoyu, Badillo Soto Felix S, Zhu Julia, Ramirez Stephen Z, Lin Hening
Abstract excerpt
Active mutations in the RAS genes are found in ∼30% of human cancers. Although thought to have overlapping functions, RAS isoforms show preferential activation in human tumors, which prompted us to employ a comparative and quantitative proteomics approach to generate isoform-specific and nucleotide-dependent interactomes of the four RAS isoforms, KRAS4A, KRAS4B, HRAS, and NRAS. Many isoform-specific interacting...
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