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Article

Structural basis for LZTR1 recognition of RAS GTPases for degradation.

Science (New York, N.Y.) - 11 Sept 2025

Dharmaiah Srisathiyanarayanan, Bonsor Daniel A, Mo Stephanie P, Fernandez-Cabrera Alvaro, Chan Albert H, Messing Simon, Drew Matthew, Vega Martha, Nissley Dwight V, Esposito Dominic, Castel Pau, Simanshu Dhirendra K

Abstract excerpt

The RAS family of small guanosine triphosphatases (GTPases) are tightly regulated signaling molecules that are further modulated by ubiquitination and proteolysis. Leucine Zipper-like Transcription Regulator 1 (LZTR1), a substrate adapter of the Cullin-3 RING E3 ubiquitin ligase, binds specific RAS GTPases and promotes their ubiquitination and proteasomal degradation. We present structures of LZTR1 Kelch domains...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40934300
DOI: 10.1126/science.adv7088
PMCID: PMC12516822

Genes

LZTR1
KRAS
MRAS
RIT1

Provenance

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