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Article

KRAS insertion mutations are oncogenic and exhibit distinct functional properties.

Nature communications - 8 Feb 2016

White Yasmine, Bagchi Aditi, Van Ziffle Jessica, Inguva Anagha, Bollag Gideon, Zhang Chao, Carias Heidi, Dickens David, Loh Mignon, Shannon Kevin, Firestone Ari J

Abstract excerpt

Oncogenic KRAS mutations introduce discrete amino acid substitutions that reduce intrinsic Ras GTPase activity and confer resistance to GTPase-activating proteins (GAPs). Here we discover a partial duplication of the switch 2 domain of K-Ras encoding a tandem repeat of amino acids G60_A66dup in a child with an atypical myeloproliferative neoplasm. K-Ras proteins containing this tandem duplication or a similar...

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Share to GTPase-Activating Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myelomonocytic, Juvenile

Share to Mutagenesis, Insertional

Share to Phosphatidylinositol 3-Kinases

Share to Proto-Oncogene Proteins c-akt

Share to Tandem Repeat Sequences

Share to Tumor Stem Cell Assay

Source

Open in PubMed Open full text

Identifiers

PMID: 26854029
DOI: 10.1038/ncomms10647
PMCID: PMC4748120

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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