A Comparative Analysis of Individual RAS Mutations in Cancer Biology

Abstract excerpt

In human cells, three closely related RAS genes, termed HRAS, KRAS and NRAS, encode four highly homologous proteins. RAS proteins are small GTPases involved in a broad spectrum of key molecular and cellular activities, including proliferation and survival among others. Gain-of-function missense mutations, mostly located at codons 12, 13 and 61, constitutively activate RAS proteins and can be detected in various...

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